CLINICAL TRIALS AND OBSERVATIONS High-dose therapy and autologous peripheral blood stem cell transplantation as salvage treatment for AIDS-related lymphoma: long-term results of the Italian Cooperative Group on AIDS and Tumors (GICAT) study with analysis of prognostic factors
نویسندگان
چکیده
1Division of Hematology, Spedali Civili di Brescia, Brescia; 2Cell Therapy and High Dose Chemotherapy Unit, National Cancer Institute, Aviano; 3Clinic of Infectious Disease, University of Brescia, Brescia; 4Division of Hematology, Ospedale SS Antonio e Biagio, Alessandria; 5Division of Medical Oncology A, National Cancer Institute, Aviano; 6Department of Laboratory Medicine and Cell Therapy, Hematopoietic Stem Cells Collection and Processing Unit, National Cancer Institute, Aviano; and 7Department of Immune-Hematology and Transfusional Medicine, Spedali Civili di Brescia, Brescia, Italy
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma
Second-line chemotherapy followed by high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) cures less than half of the patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Prognostic models capable of predicting outcome are essential. In 3 sequential clinical trials, conducted from January 1993 to August 2000, we treated 150 patients with relapsed or pr...
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We used a sensitive real-time reverse transcription–polymerase chain reaction assay to quantify cyclin D1 mRNA levels in bone marrow samples collected at diagnosis from 74 newly diagnosed multiple myeloma (MM) patients who were randomized to undergo either single or double autologous peripheral blood stem cell transplantation as part of first-line therapy for their malignancy. In 46 cases, fluo...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Standard chemotherapy with interferon compared with CHOP followed by high-dose therapy with autologous stem cell transplantation in untreated patients with advanced follicular lymphoma: the GELF-94 randomized study from the Groupe d’Etude des Lymphomes de l’Adulte (GELA)
The purpose of this study is to compare our standard chemotherapy regimen (CHVP [cyclophosphamide, doxorubicin, teniposide, and prednisone]) plus interferon with 4 courses of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) followed by high-dose therapy with autologous stem cell transplantation (ASCT) in treatment-naive patients with advanced follicular lymphoma. Four hundred o...
متن کاملPrognostic analysis of early lymphocyte recovery in patients with advanced breast cancer receiving high-dose chemotherapy with an autologous hematopoietic progenitor cell transplant.
PURPOSE The purpose of this study was to evaluate the prognostic effect of early posttransplant lymphocyte recovery in patients with advanced breast cancer receiving high-dose chemotherapy with autologous hematopoietic progenitor cell transplantation. EXPERIMENTAL DESIGN We analyzed the effect of the absolute lymphocyte count on day +15 posttransplant on freedom from relapse and overall survi...
متن کاملHigh-dose chemotherapy and autologous stem cell transplantation for secondary central nervous system lymphoma: many are called, but few are chosen.
R elapse of systemic lymphoma within the central nervous system (CNS) is a devastating event with very few long-term survivors after treatment with conventional therapy. High-dose chemotherapy employing CNS-penetrating agents with autologous stem cell support has demonstrated promise in prospective trials in primary CNS lymphoma, 1 and so has naturally gar-nered attention in secondary CNS lymph...
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